Xenadrine Review

Xenadrine Review

In a study funded by Cytodyne Technologies, the makers of Xenadrine Rfa 1, researchers put subjects on a cross-training fitness program three days a week. Half the group was given Xenadrine and the other half a placebo.

Upon the conclusion of the eight-week study, researchers found that the Xenadrine review group increased the rate of fat-loss significantly more than the placebo group. Xenadrine also reduced test subject's total body-weight which left the subjects significantly leaner and more toned. The study was published in the prestigious journal, Current Therapeutic Research and presented at the annual conference of the North American Association for the Study of Obesity.

In another Cytodyne Technology-funded clinical study, researchers from Eastern Michigan University studied Xenadrine's effectiveness on 20 obese individuals. Half the group received Xenadrine and the other half a placebo. At the conclusion of the six-week study, the Xenadrine test subjects lost 524% more total fat and 759% more weight than the placebo group. These numbers are even more impressive when you consider that at the same time they were losing the fat, the Xenadrine review group actually gained 61% more lean body mass.

This study was published in the Journal of Exercise Physiology, May 2001.

While many people would question the validity of clinical studies that are funded by the manufacturer of the product in question, the combination of ephedrine, caffeine and aspirin is a widely documented nutritional method of inducing weight-loss. Numerous studies have confirmed the effectiveness of the ingredients contained in Xenadrine Rfa 1. (For a discussion of what results you can expect when taking Xenadrine, see Xenadrine Results.)

Xenadrine Review: Ingredients In Xenadrine Rfa 1

Ephedrine and Caffeine

Renowned weight-loss expert Arne Astrup, MD, and his associates performed a study with ephedrine at the University of Copenhagen and two Danish hospitals. Five young females were given 20 mg of ephedrine three times per day one hour before meals and were told to continue eating normally. Even though there was no dieting involved, the women lost an average of 2.5 kg of body weight after four weeks and 5.5 kg after 12 weeks. They also held onto their lean muscle, while their body-fat percentage dropped by 3.5% after four weeks and 5.2% after 12 weeks. Two months after the experiment stopped, they had only gained back 0.5 kg. The only side effect was a mild rise in blood pressure at the start of the experiment.

Two studies by the same Danish researchers indicate the benefits of combining ephedrine with caffeine. In both studies, the participants took a supplement with 20 mg of ephedrine and 200 mg of caffeine three times per day. They also followed a low-calorie diet. In the first study, the test subjects lost 16.2% of their body weight in 24 weeks, significantly more than the 13.4% loss by the placebo group. The second study confirmed that most of this loss was body fat. In that eight-week study, the E/C group lost 10.1 kg, compared to only 8.4 kg with the placebo. But the E/C group lost twice as much fat (9.0 kg vs. 4.5 kg) and much less fat-free mass (1.1 kg vs. 3.9 kg). Only mild side effects were reported.

The E/C combination has been studied extensively, but space limitations do not allow a detailed listing of the numerous studies that have showed weight loss benefits. All of this research, however, does support the effectiveness of the E/C stack and demonstrates the moderate level of side effects when you take appropriate dosages. (For more information on the side effects of Xenadrine Rfa 1, see Xenadrine Side Effects.)

Willow bark extract

Several studies have shown that aspirin contributes to energy expenditure, particularly in obese individuals. It appears to do this by raising the body's internal "thermostat," so that the increased production of heat produced by E/C products does not trigger a response by the body. This allows fat burning to continue longer than it otherwise would. Although no study has compared the benefits of the E/C stack with and without willow bark, the effects are probably similar to those of aspirin.

Citrus aurantium

A study published in Current Therapeutic Research recently investigated the weight-loss benefits of a supplement containing Citrus aurantium, caffeine and St. John's wort. The researchers divided 23 overweight individuals into three groups. One was given the Citrus aurantium combination. Another group got a placebo, while the third group did not receive any supplement. All of the subjects followed the same exercise and diet routine for six weeks. By the end of the experiment, the Citrus aurantium group had lost 13% of their fat mass while increasing their basal metabolic rate by 3%. While the St. John's wort, an herbal antidepressant, may have reduced appetite to some extent (people tend to eat more when they are depressed), the researchers felt that the synephrine/caffeine part of the formulation was the primary reason for the benefits in fat loss and enhanced metabolism. No published studies have examined the benefits of Citrus aurantium on its own.

L-tyrosine

Research suggests that supplementing with tyrosine may minimize the degradation of the neurotransmitters involved in the metabolic process while enhancing the thermogenic effects of the ECA stack. With more raw material available, the neurotransmitters controlling metabolism are produced at a higher level with beneficial results. The increases in alertness and energy level will also make it easier to stick to your diet program.

Ginger root

Ginger has a long history of use as a treatment for motion sickness. In one double-blind, placebo-controlled study by Danish researchers, naval cadets unaccustomed to sailing in rough seas were given 1 gm of ginger root or placebo every hour for four hours. The ginger root reduced the tendency toward vomiting and cold sweating. Thermogenic formulations only produce gastrointestinal distress in some sensitive individuals, so ginger should definitely be able to relieve these much milder symptoms. There are no studies showing that ginger by itself has fat-burning properties.

Acetyl-L-carnitine

While carnitine is discussed in many different review articles as a factor in fat metabolism, there is little research on the benefits of carnitine supplementation. One study at the University of Connecticut found that L-carnitine tartrate reduces the muscle disruption that usually occurs during weight training by 41% to 45%. Since exercise should be an important part of your weight-loss strategy (both to build muscle and to increase caloric expenditure), this ought to promote your fat-burning efforts by enhancing your recovery from the rigors of your workout program.

Because acetyl-L-carnitine contains an acetyl group, it can boost the levels of acetyl-CoA (an important intermediary in energy production) and the neurotransmitter acetylcholine. This can increase your attention span and energy level, indirectly helping you to stick to your diet program. No published studies have looked at the thermogenic potential of L-carnitine and acetyl-L-carnitine together or separately.

Fisetin

Fisetin helps caffeine and Citrus aurantium to work better by boosting the effects of epinephrine. Rat studies have shown a greater mobilization of fat-burning enzymes in the fat cells after fisetin administration. This is likely due to the greater delivery of epinephrine through the beta-adrenergic receptors of the fat-call membrane.

Magnesium phosphate

In a study published in the Journal of Physiology and Pharmacology, researchers studied the effects of phosphate supplementation on metabolic rate during a weight-loss program. For eight weeks, 36 overweight women followed a 1,000-calorie diet and were instructed to maintain their normal activity patterns. During the first four weeks, half of the women took a phosphate supplement while the other half consumed a placebo. In the second four weeks, the groups switched. The women in the phosphate group had resting metabolic rates that were 12% to 19% higher than those in the placebo group. According to the researchers, this was due to the supplement's ability to maintain the level of thyroid hormone T3 higher than it otherwise would have been.

DMAE

DMAE can enhance acetylcholine function in the central nervous system. The end result in more energy and alertness, potentially boosting your willpower as you cut your calories. While DMAE has been shown to increase mental functioning in many disease conditions (including Alzheimer's disease and attention deficit disorder), no one has yet studied its impact on fat loss as a separate supplement.

To compare prices of Xenadrine Rfa 1 among dozens of top on-line sites, see Cheapest Xenadrine Online.

For more information about how Xenadrine Rfa 1 works, see Does Xenadrine Work.