Xenical Reviews
Before Xenical
reached the market, it was tested in seven clinical trials (the
European Multicentre Orlistat Study) in which more than 4,000
obese people participated. In each case, orlistat was used along
with a low calorie, low-fat diet and regular exercise. Overall,
57 percent of people taking orlistat lost at least 5 percent of
their original body weight, compared to 31 percent of participants
who took placebos.
In one study,
people who took orlistat lost an average of 22.7 pounds compared
with 13.4 pounds among people who took placebos. Results of a
two-year study show that participants who followed a weight-loss
plan for 1 year and then switched to a weight-maintenance plan
for another year regained some of the weight they lost, even though
they continued to take orlistat. Those who continued to take the
drug, however, regained less weight than people who did not take
orlistat.
The investigators
with the European Multicentre Orlistat Study Group concluded that
orlistat is effective for weight control when used along with
a calorie-controlled diet in people who are at high risk for hypertension,
type II diabetes, or heart disease. Unlike most weight-loss products,
orlistat appears to be effective for long-term use when used in
conjunction with a low-calorie diet. However, they emphasize that
the use of the drug beyond a 2-year period needs to be carefully
monitored. For more information on side effects associated with
Xenical, visit Xenical Side
Affects.
Clinical trials
show that people who follow a reduced-calorie diet and take Xenical
for 6 to 12 months lose about 17 lbs to 22 lbs, while people who
follow the same diet but do not take Xenical lose about 11 lbs
to 13 lbs.
About 40%
of people who take Xenical and follow a low-calorie diet lose
more than 10% of their body weight, compared with about 20% of
people who use diet only.
After 2 years
of taking Xenical, 57.1% of people maintain a weight loss of at
least 5% of their original body weight, compared with 37.4% of
people who follow the same diet but do not take Xenical. Also,
34.1% maintain a weight loss of at least 10% of their original
body weight, compared with 17.5% of people who follow the same
diet but do not take Xenical.
In May 2000,
researchers at St. Luke's-Roosevelt Hospital in New York City
reported that orlistat may be useful in the treatment of diabetes.
The investigators found that orlistat can reverse high blood-sugar
levels and perhaps even prevent type II diabetes in obese individuals
when it is taken along with a conventional weight-loss program.
To compare
prices of Xenical among several top on-line pharmacies, visit
Cheapest Xenical Online.
Partial List
of Reviews and Studies on Meridia:
Davidson,
M.H., et al. Weight and risk factor reduction in obese subjects
treated for 2 years with orlistat. JAMA, 1999, 281:235-42.
Hollander,
P.A., et al. Role of orlistat in the treatment of obese patients
with type 2 diabetes. Diabetes Care, 1998, 21:1288-94.
James, W.P.T.,
et al. (1997). A one-year trial to assess the value of orlistat
in the management of obesity. International Journal of Obesity,
21(Suppl 3): S24–S30.
Sheen, A.
J., et al., Pharmacy-clinics medication of the month. Orlistat.
Rev Med Liege, Mar. 1999, 54(3): 192-96.
Sheen, A.J.,
Study of the month: Long-term (1-2) years clinical trials with
orlistat: a new drug for the treatment of obesity. Rev Med
Liege, Aug. 1999, 54(8): 707-9.
Sjostrom,
L., et al. Randomised placebo-controlled trial of orlistat for
weight loss and prevention of weight regain in obese patients.
Lancet, 1998, 352:167-73.
Van Gaal,
L.F., et al. (1998). Efficacy and tolerability of orlistat in
the treatment of obesity: A 6-month dose-ranging study. European
Journal of Clinical Pharmacology, 54: 125–132.
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